RESILIENCE: Phase III Randomized, Double-Blind Trial Comparing Sorafenib With Capecitabine Versus Placebo With Capecitabine in Locally Advanced or Metastatic HER2-Negative Breast Cancer.
Identifieur interne : 000512 ( Main/Exploration ); précédent : 000511; suivant : 000513RESILIENCE: Phase III Randomized, Double-Blind Trial Comparing Sorafenib With Capecitabine Versus Placebo With Capecitabine in Locally Advanced or Metastatic HER2-Negative Breast Cancer.
Auteurs : José Baselga [États-Unis] ; Claudio Zamagni [Italie] ; Patricia G Mez [Espagne] ; Bego A Bermejo [Espagne] ; Shigenori E. Nagai [Japon] ; Bohuslav Melichar [République tchèque] ; Arlene Chan [Australie] ; Lászlo Mángel [Hongrie] ; Jonas Bergh [Suède] ; Frederico Costa [Brésil] ; Henry L. G Mez [Pérou] ; William J. Gradishar [États-Unis] ; Clifford A. Hudis [États-Unis] ; Bernardo L. Rapoport [Afrique du Sud] ; Henri Roché [France] ; Patricia Maeda [États-Unis] ; Liping Huang [États-Unis] ; Gerold Meinhardt [États-Unis] ; Joshua Zhang [États-Unis] ; Lee S. Schwartzberg [États-Unis]Source :
- Clinical breast cancer [ 1938-0666 ] ; 2017.
Abstract
Sorafenib is a multikinase inhibitor with antiangiogenic/antiproliferative activity. In this randomized, double-blind, placebo-controlled phase III trial, we assessed first- or second-line capecitabine with sorafenib or placebo in patients with locally advanced/metastatic HER2-negative breast cancer resistant to a taxane and anthracycline and with known estrogen/progesterone receptor status.
DOI: 10.1016/j.clbc.2017.05.006
PubMed: 28830796
Affiliations:
- Afrique du Sud, Australie, Brésil, Espagne, France, Hongrie, Italie, Japon, Pérou, République tchèque, Suède, États-Unis
- Catalogne, Illinois, Midi-Pyrénées, New Jersey, Occitanie (région administrative), Svealand, Tennessee, État de New York, État de São Paulo
- Barcelone, Stockholm, São Paulo, Toulouse
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">RESILIENCE: Phase III Randomized, Double-Blind Trial Comparing Sorafenib With Capecitabine Versus Placebo With Capecitabine in Locally Advanced or Metastatic HER2-Negative Breast Cancer.</title><author><name sortKey="Baselga, Jose" sort="Baselga, Jose" uniqKey="Baselga J" first="José" last="Baselga">José Baselga</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: baselgaj@mskcc.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Zamagni, Claudio" sort="Zamagni, Claudio" uniqKey="Zamagni C" first="Claudio" last="Zamagni">Claudio Zamagni</name><affiliation wicri:level="1"><nlm:affiliation>S. Orsola Malpighi Hospital, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>S. Orsola Malpighi Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="G Mez, Patricia" sort="G Mez, Patricia" uniqKey="G Mez P" first="Patricia" last="G Mez">Patricia G Mez</name><affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bermejo, Bego A" sort="Bermejo, Bego A" uniqKey="Bermejo B" first="Bego A" last="Bermejo">Bego A Bermejo</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Clínico Universitario de Valencia, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínico Universitario de Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Nagai, Shigenori E" sort="Nagai, Shigenori E" uniqKey="Nagai S" first="Shigenori E" last="Nagai">Shigenori E. Nagai</name><affiliation wicri:level="1"><nlm:affiliation>Saitama Cancer Center, Saitama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Saitama Cancer Center, Saitama</wicri:regionArea><wicri:noRegion>Saitama</wicri:noRegion></affiliation></author><author><name sortKey="Melichar, Bohuslav" sort="Melichar, Bohuslav" uniqKey="Melichar B" first="Bohuslav" last="Melichar">Bohuslav Melichar</name><affiliation wicri:level="1"><nlm:affiliation>Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Palacky University Medical School and Teaching Hospital, Olomouc</wicri:regionArea><wicri:noRegion>Olomouc</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Arlene" sort="Chan, Arlene" uniqKey="Chan A" first="Arlene" last="Chan">Arlene Chan</name><affiliation wicri:level="1"><nlm:affiliation>Curtin Health Innovation Research Institute, Curtin University, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Mangel, Laszlo" sort="Mangel, Laszlo" uniqKey="Mangel L" first="Lászlo" last="Mángel">Lászlo Mángel</name><affiliation wicri:level="1"><nlm:affiliation>University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Bergh, Jonas" sort="Bergh, Jonas" uniqKey="Bergh J" first="Jonas" last="Bergh">Jonas Bergh</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet and University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet and University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Costa, Frederico" sort="Costa, Frederico" uniqKey="Costa F" first="Frederico" last="Costa">Frederico Costa</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Sírio Libanês, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio Libanês, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="G Mez, Henry L" sort="G Mez, Henry L" uniqKey="G Mez H" first="Henry L" last="G Mez">Henry L. G Mez</name><affiliation wicri:level="1"><nlm:affiliation>Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Instituto Nacional de Enfermedades Neoplásicas, Lima</wicri:regionArea><wicri:noRegion>Lima</wicri:noRegion></affiliation></author><author><name sortKey="Gradishar, William J" sort="Gradishar, William J" uniqKey="Gradishar W" first="William J" last="Gradishar">William J. Gradishar</name><affiliation wicri:level="2"><nlm:affiliation>Northwestern University Feinberg School of Medicine, Chicago, IL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Hudis, Clifford A" sort="Hudis, Clifford A" uniqKey="Hudis C" first="Clifford A" last="Hudis">Clifford A. 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Rapoport</name><affiliation wicri:level="1"><nlm:affiliation>The Medical Oncology Center of Rosebank and Linksfield Park Hospital, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The Medical Oncology Center of Rosebank and Linksfield Park Hospital, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author><author><name sortKey="Roche, Henri" sort="Roche, Henri" uniqKey="Roche H" first="Henri" last="Roché">Henri Roché</name><affiliation wicri:level="3"><nlm:affiliation>Institut Claudius Régaud, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Claudius Régaud, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Maeda, Patricia" sort="Maeda, Patricia" uniqKey="Maeda P" first="Patricia" last="Maeda">Patricia Maeda</name><affiliation wicri:level="2"><nlm:affiliation>Bayer HealthCare Pharmaceuticals, Whippany, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Bayer HealthCare Pharmaceuticals, Whippany</wicri:cityArea></affiliation></author><author><name sortKey="Huang, Liping" sort="Huang, Liping" uniqKey="Huang L" first="Liping" last="Huang">Liping Huang</name><affiliation wicri:level="2"><nlm:affiliation>Bayer HealthCare Pharmaceuticals, Whippany, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Bayer HealthCare Pharmaceuticals, Whippany</wicri:cityArea></affiliation></author><author><name sortKey="Meinhardt, Gerold" sort="Meinhardt, Gerold" uniqKey="Meinhardt G" first="Gerold" last="Meinhardt">Gerold Meinhardt</name><affiliation wicri:level="2"><nlm:affiliation>Bayer HealthCare Pharmaceuticals, Whippany, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Bayer HealthCare Pharmaceuticals, Whippany</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Joshua" sort="Zhang, Joshua" uniqKey="Zhang J" first="Joshua" last="Zhang">Joshua Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Bayer HealthCare Pharmaceuticals, Whippany, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Bayer HealthCare Pharmaceuticals, Whippany</wicri:cityArea></affiliation></author><author><name sortKey="Schwartzberg, Lee S" sort="Schwartzberg, Lee S" uniqKey="Schwartzberg L" first="Lee S" last="Schwartzberg">Lee S. Schwartzberg</name><affiliation wicri:level="2"><nlm:affiliation>The West Clinic, Memphis, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>The West Clinic, Memphis</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28830796</idno><idno type="pmid">28830796</idno><idno type="doi">10.1016/j.clbc.2017.05.006</idno><idno type="wicri:Area/PubMed/Corpus">000B71</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B71</idno><idno type="wicri:Area/PubMed/Curation">000B68</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B68</idno><idno type="wicri:Area/PubMed/Checkpoint">000B68</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B68</idno><idno type="wicri:Area/Ncbi/Merge">004D20</idno><idno type="wicri:Area/Ncbi/Curation">004D20</idno><idno type="wicri:Area/Ncbi/Checkpoint">004D20</idno><idno type="wicri:Area/Main/Merge">000507</idno><idno type="wicri:Area/Main/Curation">000512</idno><idno type="wicri:Area/Main/Exploration">000512</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">RESILIENCE: Phase III Randomized, Double-Blind Trial Comparing Sorafenib With Capecitabine Versus Placebo With Capecitabine in Locally Advanced or Metastatic HER2-Negative Breast Cancer.</title><author><name sortKey="Baselga, Jose" sort="Baselga, Jose" uniqKey="Baselga J" first="José" last="Baselga">José Baselga</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: baselgaj@mskcc.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Zamagni, Claudio" sort="Zamagni, Claudio" uniqKey="Zamagni C" first="Claudio" last="Zamagni">Claudio Zamagni</name><affiliation wicri:level="1"><nlm:affiliation>S. Orsola Malpighi Hospital, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>S. Orsola Malpighi Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="G Mez, Patricia" sort="G Mez, Patricia" uniqKey="G Mez P" first="Patricia" last="G Mez">Patricia G Mez</name><affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bermejo, Bego A" sort="Bermejo, Bego A" uniqKey="Bermejo B" first="Bego A" last="Bermejo">Bego A Bermejo</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Clínico Universitario de Valencia, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clínico Universitario de Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Nagai, Shigenori E" sort="Nagai, Shigenori E" uniqKey="Nagai S" first="Shigenori E" last="Nagai">Shigenori E. Nagai</name><affiliation wicri:level="1"><nlm:affiliation>Saitama Cancer Center, Saitama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Saitama Cancer Center, Saitama</wicri:regionArea><wicri:noRegion>Saitama</wicri:noRegion></affiliation></author><author><name sortKey="Melichar, Bohuslav" sort="Melichar, Bohuslav" uniqKey="Melichar B" first="Bohuslav" last="Melichar">Bohuslav Melichar</name><affiliation wicri:level="1"><nlm:affiliation>Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Palacky University Medical School and Teaching Hospital, Olomouc</wicri:regionArea><wicri:noRegion>Olomouc</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Arlene" sort="Chan, Arlene" uniqKey="Chan A" first="Arlene" last="Chan">Arlene Chan</name><affiliation wicri:level="1"><nlm:affiliation>Curtin Health Innovation Research Institute, Curtin University, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Curtin Health Innovation Research Institute, Curtin University, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Mangel, Laszlo" sort="Mangel, Laszlo" uniqKey="Mangel L" first="Lászlo" last="Mángel">Lászlo Mángel</name><affiliation wicri:level="1"><nlm:affiliation>University of Pécs, Pécs, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>University of Pécs, Pécs</wicri:regionArea><wicri:noRegion>Pécs</wicri:noRegion></affiliation></author><author><name sortKey="Bergh, Jonas" sort="Bergh, Jonas" uniqKey="Bergh J" first="Jonas" last="Bergh">Jonas Bergh</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet and University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet and University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Costa, Frederico" sort="Costa, Frederico" uniqKey="Costa F" first="Frederico" last="Costa">Frederico Costa</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Sírio Libanês, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio Libanês, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="G Mez, Henry L" sort="G Mez, Henry L" uniqKey="G Mez H" first="Henry L" last="G Mez">Henry L. G Mez</name><affiliation wicri:level="1"><nlm:affiliation>Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Instituto Nacional de Enfermedades Neoplásicas, Lima</wicri:regionArea><wicri:noRegion>Lima</wicri:noRegion></affiliation></author><author><name sortKey="Gradishar, William J" sort="Gradishar, William J" uniqKey="Gradishar W" first="William J" last="Gradishar">William J. Gradishar</name><affiliation wicri:level="2"><nlm:affiliation>Northwestern University Feinberg School of Medicine, Chicago, IL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Hudis, Clifford A" sort="Hudis, Clifford A" uniqKey="Hudis C" first="Clifford A" last="Hudis">Clifford A. Hudis</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Rapoport, Bernardo L" sort="Rapoport, Bernardo L" uniqKey="Rapoport B" first="Bernardo L" last="Rapoport">Bernardo L. Rapoport</name><affiliation wicri:level="1"><nlm:affiliation>The Medical Oncology Center of Rosebank and Linksfield Park Hospital, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>The Medical Oncology Center of Rosebank and Linksfield Park Hospital, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author><author><name sortKey="Roche, Henri" sort="Roche, Henri" uniqKey="Roche H" first="Henri" last="Roché">Henri Roché</name><affiliation wicri:level="3"><nlm:affiliation>Institut Claudius Régaud, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Claudius Régaud, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Maeda, Patricia" sort="Maeda, Patricia" uniqKey="Maeda P" first="Patricia" last="Maeda">Patricia Maeda</name><affiliation wicri:level="2"><nlm:affiliation>Bayer HealthCare Pharmaceuticals, Whippany, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Bayer HealthCare Pharmaceuticals, Whippany</wicri:cityArea></affiliation></author><author><name sortKey="Huang, Liping" sort="Huang, Liping" uniqKey="Huang L" first="Liping" last="Huang">Liping Huang</name><affiliation wicri:level="2"><nlm:affiliation>Bayer HealthCare Pharmaceuticals, Whippany, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Bayer HealthCare Pharmaceuticals, Whippany</wicri:cityArea></affiliation></author><author><name sortKey="Meinhardt, Gerold" sort="Meinhardt, Gerold" uniqKey="Meinhardt G" first="Gerold" last="Meinhardt">Gerold Meinhardt</name><affiliation wicri:level="2"><nlm:affiliation>Bayer HealthCare Pharmaceuticals, Whippany, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Bayer HealthCare Pharmaceuticals, Whippany</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Joshua" sort="Zhang, Joshua" uniqKey="Zhang J" first="Joshua" last="Zhang">Joshua Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Bayer HealthCare Pharmaceuticals, Whippany, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Bayer HealthCare Pharmaceuticals, Whippany</wicri:cityArea></affiliation></author><author><name sortKey="Schwartzberg, Lee S" sort="Schwartzberg, Lee S" uniqKey="Schwartzberg L" first="Lee S" last="Schwartzberg">Lee S. Schwartzberg</name><affiliation wicri:level="2"><nlm:affiliation>The West Clinic, Memphis, TN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>The West Clinic, Memphis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical breast cancer</title><idno type="eISSN">1938-0666</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sorafenib is a multikinase inhibitor with antiangiogenic/antiproliferative activity. In this randomized, double-blind, placebo-controlled phase III trial, we assessed first- or second-line capecitabine with sorafenib or placebo in patients with locally advanced/metastatic HER2-negative breast cancer resistant to a taxane and anthracycline and with known estrogen/progesterone receptor status.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>Brésil</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Italie</li><li>Japon</li><li>Pérou</li><li>République tchèque</li><li>Suède</li><li>États-Unis</li></country><region><li>Catalogne</li><li>Illinois</li><li>Midi-Pyrénées</li><li>New Jersey</li><li>Occitanie (région administrative)</li><li>Svealand</li><li>Tennessee</li><li>État de New York</li><li>État de São Paulo</li></region><settlement><li>Barcelone</li><li>Stockholm</li><li>São Paulo</li><li>Toulouse</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Baselga, Jose" sort="Baselga, Jose" uniqKey="Baselga J" first="José" last="Baselga">José Baselga</name></region><name sortKey="Gradishar, William J" sort="Gradishar, William J" uniqKey="Gradishar W" first="William J" last="Gradishar">William J. Gradishar</name><name sortKey="Huang, Liping" sort="Huang, Liping" uniqKey="Huang L" first="Liping" last="Huang">Liping Huang</name><name sortKey="Hudis, Clifford A" sort="Hudis, Clifford A" uniqKey="Hudis C" first="Clifford A" last="Hudis">Clifford A. Hudis</name><name sortKey="Maeda, Patricia" sort="Maeda, Patricia" uniqKey="Maeda P" first="Patricia" last="Maeda">Patricia Maeda</name><name sortKey="Meinhardt, Gerold" sort="Meinhardt, Gerold" uniqKey="Meinhardt G" first="Gerold" last="Meinhardt">Gerold Meinhardt</name><name sortKey="Schwartzberg, Lee S" sort="Schwartzberg, Lee S" uniqKey="Schwartzberg L" first="Lee S" last="Schwartzberg">Lee S. Schwartzberg</name><name sortKey="Zhang, Joshua" sort="Zhang, Joshua" uniqKey="Zhang J" first="Joshua" last="Zhang">Joshua Zhang</name></country><country name="Italie"><noRegion><name sortKey="Zamagni, Claudio" sort="Zamagni, Claudio" uniqKey="Zamagni C" first="Claudio" last="Zamagni">Claudio Zamagni</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="G Mez, Patricia" sort="G Mez, Patricia" uniqKey="G Mez P" first="Patricia" last="G Mez">Patricia G Mez</name></region><name sortKey="Bermejo, Bego A" sort="Bermejo, Bego A" uniqKey="Bermejo B" first="Bego A" last="Bermejo">Bego A Bermejo</name></country><country name="Japon"><noRegion><name sortKey="Nagai, Shigenori E" sort="Nagai, Shigenori E" uniqKey="Nagai S" first="Shigenori E" last="Nagai">Shigenori E. Nagai</name></noRegion></country><country name="République tchèque"><noRegion><name sortKey="Melichar, Bohuslav" sort="Melichar, Bohuslav" uniqKey="Melichar B" first="Bohuslav" last="Melichar">Bohuslav Melichar</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Chan, Arlene" sort="Chan, Arlene" uniqKey="Chan A" first="Arlene" last="Chan">Arlene Chan</name></noRegion></country><country name="Hongrie"><noRegion><name sortKey="Mangel, Laszlo" sort="Mangel, Laszlo" uniqKey="Mangel L" first="Lászlo" last="Mángel">Lászlo Mángel</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Bergh, Jonas" sort="Bergh, Jonas" uniqKey="Bergh J" first="Jonas" last="Bergh">Jonas Bergh</name></region></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Costa, Frederico" sort="Costa, Frederico" uniqKey="Costa F" first="Frederico" last="Costa">Frederico Costa</name></region></country><country name="Pérou"><noRegion><name sortKey="G Mez, Henry L" sort="G Mez, Henry L" uniqKey="G Mez H" first="Henry L" last="G Mez">Henry L. G Mez</name></noRegion></country><country name="Afrique du Sud"><noRegion><name sortKey="Rapoport, Bernardo L" sort="Rapoport, Bernardo L" uniqKey="Rapoport B" first="Bernardo L" last="Rapoport">Bernardo L. Rapoport</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Roche, Henri" sort="Roche, Henri" uniqKey="Roche H" first="Henri" last="Roché">Henri Roché</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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